ALS-associated mutations reveal a conserved C-terminal self-assembly module in the TDP-43 low-complexity domain
Nobuo Maita, Sunyong Kim, 梶野裕子, Masato Kato
The paper identifies the C-terminal conserved region (CCR) of TDP-43 as a self-assembly module, showing that ALS-associated mutations impair fibrillization and assembly kinetics.
bioRxiv · Oct 12, 2026 · PreprintBiochemistry