Human ribomes reveal DNA-embedded ribonucleotides as a new type of epigenetic mark
Deepali L. Kundnani, Taehwan Yang, Tejasvi Channagiri, Penghao Xu, Yeunsoo Lee, Mo Sun, Francisco Martinez-Figueroa, Supreet Randhawa, Ashlesha Gogate, Youngkyu Jeon, Stefania Marsili, Gary P. Newnam, Yilin Lu, Vivian S. Park, Sijia Tao, , Francesca Storici
The paper maps DNA-embedded ribonucleotides (rNMPs) across human cell types, revealing their non-random distribution and role as a novel epigenetic mark affecting gene expression.
bioRxiv · Jun 27, 2025 · PreprintMolecular Biology