Systems BiologyAntimicrobial Agents and ChemotherapyPeer-reviewed
A roadblock-and-kill model explains the dynamical response to the DNA-targeting antibiotic ciprofloxacin
Nikola Ojkic, Elin Lilja, Susana O. L. Direito…·Bartłomiej Waclaw
The paper develops a roadblock-and-kill model to explain how E. coli responds dynamically to ciprofloxacin, showing that DNA replication blockage, not the SOS response, drives growth inhibition.
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