Assessing the co-variability of DNA methylation across peripheral cells and tissues: implications for the interpretation of findings in epigenetic epidemiology
Eilis J. Hannon, Georgina Mansell, Emma Walker, Marta F. Nabais, Joe Burrage, Agnieszka Kepa, Janis Best-Lane, Anna Rose, Suzanne Heck, Terrie E. Moffitt, Avshalom Caspi, Louise Arseneault, Jonathan S. Mill
This study examines DNA methylation differences across blood cell types and tissues, showing that whole blood DNAm reflects contributions from multiple cell types rather than being cell-type specific.
PLoS Genetics · Mar 19, 2021Peer-reviewedGenomics