Avshalom Caspi

The paper develops a reproducibility-based framework for creating DNA methylation algorithms on the MSA, showing that stable probe sets can support new biomarkers and transfer of existing ones with improved performance.

This study identifies a shared genetic factor underlying brain age gaps across 30 cohorts, finding 19 SNPs and associations with health traits.

The paper updates a polygenic index repository with more phenotypes, datasets, and improved causal inference methods, enhancing predictive performance and interpretability.

The paper compares epigenetic aging clocks across different tissue types, finding significant differences in age estimates between oral and blood-based tissues.

The paper introduces DunedinPACNI, a brain MRI-based aging measure that predicts dementia conversion, morbidity, and mortality.

This study compares feature selection methods and machine learning algorithms to develop a DNA methylation-based telomere length estimator, finding that principal component analysis followed by elastic net regression performs best.

The paper examines how functional topography of neocortical networks in midlife relates to covariation in motor and cognitive abilities, finding that motor ability reflects functional topography differences while hearing does not.

This study identifies genetic variants associated with antisocial behavior through a genome-wide association meta-analysis, finding significant links to FOXP2 and correlations with multiple health and behavioral traits.

The paper identifies genetic variants influencing DNA methylation in blood and shows their associations with complex traits and diseases, but finds limited direct causality.

The paper constructs polygenic indexes for 47 phenotypes across 11 datasets and provides a tool to correct errors-in-variables bias when using PGIs as proxies for the additive SNP factor.

This study examines DNA methylation differences across blood cell types and tissues, showing that whole blood DNAm reflects contributions from multiple cell types rather than being cell-type specific.

This study identifies 157 genome-wide significant loci associated with non-cognitive contributions to educational attainment, explaining 57% of genetic variance.

This paper identifies DNA methylation sites associated with aggression through a meta-analysis of epigenome-wide studies across different age groups and tissues.

The paper identifies a common pattern of reduced neocortical thickness across multiple psychiatric disorder categories and the general psychopathology factor.

The paper develops a DNA methylation-based blood test, DunedinPoAm, to quantify individual differences in the pace of biological aging and validates its association with aging-related outcomes across multiple studies.

Task-fMRI regional activation has poor test-retest reliability: meta-analytic mean intraclass correlation .397 across 77 un-thresholded substudies, and .067 to .485 for 11 tasks in HCP and Dunedin retest samples.

This study shows that older brain-age in midlife is linked to accelerated biological aging and cognitive decline, supporting brain-age as a biomarker while highlighting its potential to reflect lifelong CNS variation.

The paper replicates structural brain alterations linked to the p factor in a longitudinal cohort, finding support for cerebello-thalamo-cortical circuit and visual association cortex associations but not cerebellar morphology.

This study examines how maternal and child genetic data relate to parenting and children's educational attainment, finding genetic and environmental interactions.

This paper introduces General Functional Connectivity (GFC) to improve reliability and heritability of intrinsic connectivity estimates by combining resting-state and task fMRI data.

This study finds that white matter hyperintensities (WMHs) are common in midlife and are associated with lower IQ and greater cognitive decline from childhood to midlife.

The paper links neighborhood data with genetic and social outcomes to assess whether neighborhood effects on health and behavior are due to selection or causation.

The paper tests the genetic p factor hypothesis by analyzing correlations across psychiatric disorders using multiple methods and finds strong support for a genetic p factor.

The paper finds that a polygenic score for educational attainment is associated with larger brain size and better cognitive test performance, suggesting a genetic link between brain size and intelligence.

This study evaluates seven biological aging measures in middle-aged humans, finding low agreement between them and modest associations with aging-related outcomes.