Positional Scanning and Computational Modeling Reveal Determinants of Legumain Transpeptidase Activity
Rupert Klaushofer, Sven O. Dahms, Hans Brandstetter, Elfriede Dall
The paper identifies key substrate determinants for human legumain-mediated peptide cyclization using positional scanning and computational modeling, and designs an optimized substrate with enhanced cyclization efficiency.
Protein Science · Apr 6, 2026Peer-reviewedBiochemistry