Author

Rupert Klaushofer

University of SalzburgORCID 0009-0009-2247-0648Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:comparative / phylogenetic analysis· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

Elfriede DalliD· 2 shared Hans BrandstetteriD· 2 shared Alexander C. WielandiD· 1 shared Carina Horak· 1 shared Peter BrizaiD· 1 shared Sven O. Dahms· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 12 mutual co-author links

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2 shared papersBiochemistry

Elfriede DallORCID

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2 papers

Recent·Most cited

BiochemistryProtein SciencePeer-reviewedApr 6, 2026

Positional Scanning and Computational Modeling Reveal Determinants of Legumain Transpeptidase Activity

Rupert Klaushofer, Sven O. Dahms, Hans Brandstetter, Elfriede Dall

The paper identifies key substrate determinants for human legumain-mediated peptide cyclization using positional scanning and computational modeling, and designs an optimized substrate with enhanced cyclization efficiency.

DOI 10.1002/pro.70563

humanproteomics

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Molecular BiologyJournal of Molecular BiologyPeer-reviewedApr 5, 2025

Conformational and Functional Regulation of SET by Legumain Cleavage

Carina Horak, Alexander C. Wieland, Rupert Klaushofer…·Elfriede Dall

This study shows legumain cleaves SET at two sites, forming a stable complex and impairing its interaction with histone 1, while also abolishing SET's positive modulation of PP2A activity.

DOI 10.1016/j.jmb.2025.169119

experimental assay

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