Clearing truncated tau protein restores neuronal function and prevents microglia activation in tauopathy mice
Alejandro Martín‐Ávila, Swananda Modak, Hameetha B. Rajamohamedsait, Andie Dodge, Dov B. Shamir, Senthilkumar Krishnaswamy, Leslie A. Sandusky‐Beltran, Marilyn Walker, Yan Lin, Erin E. Congdon, Einar M. Sigurdsson
This study shows that targeting truncated tau protein with a monoclonal antibody reduces tau levels, improves neuronal function, and decreases microglia activation in tauopathy mouse models.
Cell Reports · Sep 17, 2025Peer-reviewedNeuroscience