Hsp10 Targets the C-Terminus of α-Synuclein to Inhibit Secondary Nucleation and Remodel Labile Fibrils
Muhammed Shafeek Oliyantakath Hassan, Sydney Call, Ayobami Tosin Adegbenro, Jakob Villarreal, Marielle Aulikki Wälti
This study identifies how Hsp10 interacts with α-synuclein to inhibit its aggregation and remodel fibrils, revealing a mechanism for its role in Parkinson's disease.
bioRxiv · Oct 25, 2026 · PreprintBiochemistry