Trisomy 21 Drives ADARB1 Overexpression and Premature RNA Recoding in the Developing Fetal Brain
Michael S. Breen, Andy Yang, Xuran Wang, Miguel Rodríguez de los Santos, Ran Tao, Daniel R. Weinberger, Joel E. Kleinman, Kalina Yonkova Mihova, Gergana S. Stancheva, Sylvia Savova, Radka Petrova Kaneva, Violeta Dimitrova, Vladimir I. Vladimirov, T M Hyde, Joseph D. Buxbaum
This study identifies ADARB1 overexpression in T21 fetal brain due to trisomy 21, leading to increased A-to-I RNA editing and altered GRIA gene recoding.
medRxiv · Nov 13, 2025 · PreprintGenetic & Genomic Medicine