A bipartite function of ESRRB can integrate signaling over time to balance self-renewal and differentiation
T. E. Knudsen, W. Hamilton, M. Proks, M. Lykkegaard, A. V. Nielsen, A. Trusina, J. M. Brickman
This study shows ESRRB supports pluripotency when NANOG is present but promotes a primitive endoderm identity when NANOG is absent, with their stoichiometry influencing differentiation.
bioRxiv · Sep 20, 2022Cell Biology