RNA binding domains of heterologous viral proteins substituted for basic residues in the RSV Gag NC domain restore specific packaging of genomic RNA
B. Rice, T. L. Lochmann, L. J. Parent
The paper replaces basic residues in RSV Gag NC with RNA-binding motifs from HIV-1 Rev and HSV ICP27 to study gRNA packaging, finding that while packaging efficiency is maintained, infectivity is lost.
bioRxiv · Mar 12, 2020Microbiology