TET2-mediated epigenetic reprogramming of breast cancer cells impairs lysosome biogenesis
A. Laurent, T. Madigou, M. Bizot, M. Turpin, G. Palierne, E. Mahe, S. Guimard, R. Metivier, S. Avner, C. Le Peron, G. Salbert
This study shows that TET2-mediated epigenetic changes in breast cancer cells reduce tumorigenic potential by altering gene expression related to lysosome biogenesis and MYC regulation.
bioRxiv · Oct 27, 2021Cancer Biology