Androgen signaling connects short isoform production to breakpoint formation at Ewing sarcoma breakpoint region 1 via an R-loop-dependent mechanism
T. R. Nicholas, P. C. Hollenhorst
The paper shows androgen signaling increases a short EWSR1 isoform by promoting an intronic polyadenylation site, which is linked to R-loop formation and breakpoint generation in Ewing sarcoma.
bioRxiv · Mar 25, 2020Cancer Biology