Improving the Generation and Selection of Virtual Populations in Quantitative Systems Pharmacology Models
T. R. Rieger, R. J. Allen, L. Bystricky, Y. Chen, G. Colopy, Y. Cui, A. Gonzalez, Y. Liu, R. White, R. Everett, H. T. Banks, C. J. Musante
The paper improves the generation of virtual populations in QSP models by using alternative optimization algorithms and objective functions to reduce the number of required virtual patients while maintaining diversity.
bioRxiv · Jan 18, 2018Pharmacology & Toxicology