R. J. Allen

Targeting of a STING Agonist to Perivascular Macrophages in Prostate Tumors Delays Resistance to Androgen Deprivation Therapy

This study shows targeting a STING agonist to perivascular macrophages in ADT-treated prostate tumors delays castration resistance prostate cancer onset.

Habitat fragmentation enhances microbial collective defence

The paper shows habitat fragmentation can enhance microbial collective defense against antibiotics by allowing subpopulations to survive higher doses.

Bacterial aggregation triggered by low-level antibiotic-mediated lysis

This study shows low-dose antibiotics trigger bacterial aggregation via lysis and extracellular DNA release, forming aggregates distinct from biofilms.

A model for quorum-sensing mediated stochastic biofilm nucleation

The paper presents a model showing how quorum sensing triggers stochastic biofilm formation through a transition between a loose bacterial layer and a growing biofilm.

Different factors control long-term versus short-term outcomes for bacterial colonisation of a urinary catheter

This study develops a mathematical model to show that long-term and short-term urinary catheter colonization are controlled by different factors, suggesting tailored management strategies for infection prevention.

Distinct types of multicellular aggregates in Pseudomonas aeruginosa liquid cultures

This study identifies two distinct types of multicellular aggregates in Pseudomonas aeruginosa cultures, mediated by different factors in exponential vs stationary phase.

Pinning transition in biofilm structure driven by active layer dynamics

This study uses simulations to show how active layer dynamics in biofilms lead to different structural phases, with pinning transitions affecting interface roughness and morphology.

Stability of β-lactam antibiotics in bacterial growth media

This study measures the degradation half-lives of β-lactam antibiotics in bacterial growth media and highlights potential issues with interpreting MIC tests due to antibiotic instability.

Predictable Properties of Fitness Landscapes Induced by Adaptational Tradeoffs

The paper develops a mathematical model of fitness landscapes shaped by adaptational tradeoffs, showing predictable properties and accessible evolutionary paths despite ruggedness.

Phenotypic delay in the evolution of bacterial antibiotic resistance: mechanistic models and their implications

The paper investigates phenotypic delay in bacterial antibiotic resistance evolution using simulations and theory, showing that dilution of sensitive molecules and effective polyploidy cause delay, affecting survival and mutation rate estimates.

Improving the Generation and Selection of Virtual Populations in Quantitative Systems Pharmacology Models

The paper improves the generation of virtual populations in QSP models by using alternative optimization algorithms and objective functions to reduce the number of required virtual patients while maintaining diversity.

Stochastic methods for inferring states of cell migration

This study develops stochastic computational tools to analyze cell migration states, revealing two distinct migration states in MEFs and HeLa cells, linked to RhoG and Rac1 activity.