Amplification, not spreading limits rate of tau aggregate accumulation in Alzheimer's disease
G. Meisl, Y. Zuo, K. Allinson, T. Rittman, S. DeVos, J. S. Sanchez, C. K. Xu, K. E. Duff, K. A. Johnson, J. Rowe, B. Hyman, T. P. Knowles, D. Klenerman
The paper quantifies tau aggregate replication rates in Alzheimer's disease and finds local replication, not spreading, limits tau accumulation in neocortical regions.
bioRxiv · Nov 16, 2020 · PreprintBiophysics