The paper introduces a biocompatible method to transfer gold nanopatterns onto live cells using biotransfer printing, showing high pattern fidelity and cell viability.

bioRxiv · May 28, 2023Bioengineering

Porous microneedle patch with sustained exosome delivery repairs severe spinal cord injury

A. Fang, Y. Wang, N. Guan, L. Lin, B. Guo, W. Cai, X. Chen, J. Ye, Z. Abdelrahman, X. Li, Y. Zuo, H. Zheng, Z. Wu, S. Jin, K. Xu, , X. Wang

This study develops a microneedle patch that delivers mesenchymal stem cell-derived exosomes to treat spinal cord injury, showing improved tissue recovery and functional outcomes in rats.

bioRxiv · Jul 18, 2022 · PreprintBioengineering

Vitamin C is an efficient natural product for prevention of SARS-CoV-2 infection by targeting ACE2 in both cell and in vivo mouse models

Y. Zuo, Z. Zheng, Y. Huang, J. He, L. Zang, T. Ren, X. Cao, Y. Miao, Y. Yuan, Y. Liu, F. Ma, S. Tian, J. Dai, Q. Ding, H. Zheng

This paper shows that Vitamin C reduces ACE2 protein levels and blocks SARS-CoV-2 infection in cell and mouse models by inhibiting USP50-ACE2 interaction.

bioRxiv · Jul 14, 2022 · PreprintMicrobiology

Injectable hydrogel embedded with mesenchymal stem cells repairs severe spinal cord injury

X. Chen, W. Lu, Y. Zuo, J. Ye, X. Li, Z. Wu, S. Jin, W. Cai, Z. Abdelrahman, T. Zhang, B. Yu, X. Gu, Z. Chen, X. Wang

This study develops an injectable hydrogel with homogenous mesenchymal stem cells to treat severe spinal cord injury in rats, showing improved functional recovery compared to intrathecal delivery.

bioRxiv · Jul 1, 2022 · PreprintBioengineering

Amplification, not spreading limits rate of tau aggregate accumulation in Alzheimer's disease

G. Meisl, Y. Zuo, K. Allinson, T. Rittman, S. DeVos, J. S. Sanchez, C. K. Xu, K. E. Duff, K. A. Johnson, J. Rowe, B. Hyman, T. P. Knowles, D. Klenerman

The paper quantifies tau aggregate replication rates in Alzheimer's disease and finds local replication, not spreading, limits tau accumulation in neocortical regions.

bioRxiv · Nov 16, 2020 · PreprintBiophysics

A general in vitro assay to study enzymatic activities of the ubiquitin system

Y. Zuo, B. K. Chong, K. Jiang, D. Finley, D. Klenerman, Y. Ye

The paper introduces a FRET-based assay to measure ubiquitination kinetics in vitro, demonstrating its versatility and compatibility with various enzyme combinations.

bioRxiv · Jan 17, 2020Biochemistry

A multi-omic cohort as a reference point for promoting a healthy human gut microbiome

Z. Jie, S. Liang, Q. Ding, F. Li, S. Tang, D. Wang, Y. Lin, P. Chen, K. Cai, X. Qiu, Q. Li, Y. Liao, D. Zhou, H. Lian, Y. Zuo, , X. Xu

The paper presents a large multi-omic cohort of 2,183 adults to identify correlations between gut microbiome features and various health-related factors, validated in an additional cohort.

bioRxiv · Nov 8, 2019Microbiology

Life history recorded in the vagino-cervical microbiome

Z. Jie, C. Chen, L. Hao, F. Li, L. Song, X. Zhang, J. Zhu, L. Tian, X. Tong, K. Cai, Y. Ju, X. Yu, Y. Li, H. Zhou, H. Lu, , H. Jia

This study analyzes the vagino-cervical microbiome of 516 women using metagenomic shotgun sequencing to explore how pregnancy, delivery, and contraception influence microbiome composition.

bioRxiv · Sep 4, 2019Microbiology

Structural and Practical Identifiability of Dual-input Kinetic Modeling in Dynamic PET of Liver Inflammation

Y. Zuo, S. Sarkar, M. T. Corwin, K. Olson, R. D. Badawi, G. Wang

This paper evaluates the structural and practical identifiability of a dual-input kinetic model for FDG PET in liver inflammation using Monte Carlo simulations and patient data.

bioRxiv · Nov 1, 2018Bioengineering

Relative Patlak Plot for Dynamic PET Parametric Imaging Without the Need for Early-time Input Function

Y. Zuo, J. Qi, G. Wang

This paper introduces a relative Patlak plot method for dynamic PET that eliminates the need for early-time input function, enabling more efficient parametric imaging with equivalent clinical utility.

bioRxiv · Feb 20, 2018Bioengineering