Progressive sub-MIC Exposure of Klebsiella pneumoniae 43816 to Cephalothin Induces the Evolution of beta-lactam Resistance without Acquisition of beta-lactamase Genes
J. R. Anderson, N. B. Lam, J. L. Jackson, S. M. Dorenkott, T. Ticer, E. Maldosevic, A. Velez, M. R. Camden, T. N. Ellis
This study shows that Klebsiella pneumoniae can develop beta-lactam resistance through mutations without acquiring beta-lactamase genes under progressive sub-MIC cephalothin exposure.
bioRxiv · Nov 19, 2021 · PreprintMicrobiology