Hypoxia causes pancreatic β-cell dysfunction by activating a transcriptional repressor BHLHE40
T. Tsuyama, Y. Sato, T. Yoshizawa, T. Matsuoka, K. Yamagata
This study identifies BHLHE40 as a hypoxia-induced transcriptional repressor that suppresses insulin secretion in pancreatic β-cells, contributing to β-cell dysfunction in type 2 diabetes.
bioRxiv · Jun 28, 2022 · PreprintBiochemistry