PKD2 is an essential ion channel subunit in the primary cilium of the renal collecting duct epithelium
X. Liu, T. Vien, J. Duan, S.-H. Sheu, P. G. DeCaen, D. E. Clapham
The paper identifies PKD2 as a functional ion channel subunit in primary cilia of renal collecting duct epithelial cells, showing it conducts potassium and sodium but little calcium and is sensitized by high cilioplasmic [Ca2+].
bioRxiv · Nov 7, 2017Biophysics