TMEM164 is an acyltransferase that forms ferroptotic polyunsaturated ether phospholipids
A. Reed, T. Ware, H. Li, J. F. Bazan, B. F. Cravatt
The paper identifies TMEM164 as an acyltransferase that produces PUFA ether phospholipids, essential for ferroptosis, and shows its absence reduces these lipids and protects cells from ferroptosis.
bioRxiv · Jul 6, 2022 · PreprintBiochemistry