Evolutionary BiologybioRxiv
Two linked loci under mutation-selection balance and Muller’s ratchet
K. A. Khudiakova, T. Y. Neretina, A. S. Kondrashov
The paper analyzes a deterministic model of deleterious mutations and negative selection at two haploid loci, showing that fixation of deleterious alleles is governed by natural selection, not random drift.
DOI 10.1016/j.jtbi.2021.110729