Provenance Attestation of Human Cells Using Physical Unclonable Functions
Yi Li, Mohammad Mahdi Bidmeshki, Taek Kang, Chance M. Nowak, Yiorgos Makris, Leonidas G. Bleris
This paper introduces CREAM-PUFs, a method to create unclonable identifiers in human cells using CRISPR and DNA repair stochasticity, enabling provenance attestation for cell line distribution.
bioRxiv · Jun 11, 2021 · PreprintSynthetic Biology