Cooperative regulation of NF-E2 related factor 1 protein stability and transcriptional activation by endoplasmic reticulum-associated degradation system mediator, Selenoprotein S/K.
Goki Yamada, Nozomi Tanaka, Yuka Kamada, Reiko U. Yoshimoto, Marino Kita, Hanae Takami, Yudai Suetsugu, Takeshi Sawada, Mizuho A. Kido, Tsukasa Okiyoneda, Tadayuki Tsujita
The paper shows SELS and SELK regulate NRF1 stability and transcriptional activity through ER-associated degradation, affecting proteasome subunit expression.
bioRxiv · May 19, 2026 · PreprintBiochemistry