A distal promoter and aberrant splicing enable canonical translation of out-of-frame proteins in Huntington's disease
Rachel Anderson, Tanishk Soni, Ankur Jain
The paper identifies a primate-specific promoter upstream of the HTT gene that enables splicing-mediated translation of out-of-frame CAG repeats in Huntington's disease.
bioRxiv · Oct 20, 2025 · PreprintMolecular Biology