Ankur Jain

This study shows that spermine induces two phase transitions in ssDNA through stacking and electrostatic interactions, with sequence-dependent behavior.

The paper shows that mRNA sequences have evolved to minimize self-association, maintaining transcriptome solubility through stable folding and reduced intermolecular contacts.

The paper shows that proteins in cell-like environments reduce RNA folding stability by passively suppressing base pairing, altering RNA structure predictions.

This study shows polyamines buffer labile iron to suppress ferroptosis by linking polyamine metabolism to iron homeostasis through a genome-wide CRISPR screen and fluorescent reporter.

The paper identifies a primate-specific promoter upstream of the HTT gene that enables splicing-mediated translation of out-of-frame CAG repeats in Huntington's disease.

The paper maps tissue-specific polyamine regulation in C. elegans, showing transport dominates over synthesis, the intestine regulates systemically, and neurons reprogram polyamine acquisition during development.

The paper shows how molecular interactions can encode multiphase architecture in cellular condensates and demonstrates a framework for engineering such structures with multiple coexisting phases.

This study introduces DMS-TRAM-seq to map RNA structure across the transcriptome, identifying structured elements and showing structural changes under stress.

This paper introduces a genetically encoded fluorescent reporter for real-time measurement of polyamine levels in single cells and identifies a link between mitochondrial respiration and polyamine import in Parkinson's disease.

This study creates programmable DNA and RNA liquids that can be tuned by sequence-specific hybridization to control their material properties.

This study identifies that CAG repeat expansions create new splice acceptor sites, leading to aberrant repeat-containing RNAs that are translated via canonical AUG-initiated mechanisms.

The paper shows that flanking sequences of CAG repeat-containing RNA affect its toxicity, non-ATG translation, and cytoplasmic aggregation, linking these to neurodegenerative disease mechanisms.