Impeding transcription of expanded microsatellite repeats by deactivated Cas9
Belinda S. Pinto, Tanvi Saxena, Ruan Oliveira, Héctor R. Méndez‐Gómez, John D. Cleary, Lance T. Denes, Ona L. McConnell, Juan D. Arboleda, Guangbin Xia, Maurice S. Swanson, Eric T. Wang
This study shows that deactivated Cas9 reduces RNA from expanded microsatellite repeats, improving disease-related outcomes in cellular models.
Molecular Cell · Oct 19, 2017Peer-reviewedMolecular Biology