Archetype analysis of multiplexed antibody imaging reveals interpretable morphological programs in optical pooled screens
Paula Pinto Coelho, Ana Carolina Leote, Heming Yao, Ping Wu, Takamasa Kudo, Hanchen Wang, Ermakov Vladimir, Alisha Saboowala, Taro Makino, Russell Littman, Romain Lopez, Joseph Kim, Tonia Hafner, Orit Rozenblatt–Rosen, David Richmond, , Aviv Regev
The paper introduces CellMAPP and CHART to analyze multiplexed antibody imaging data, revealing modular morphological programs in response to genetic perturbations.
bioRxiv · Oct 9, 2026 · PreprintSystems Biology