Polymorphisms in Intron 1 of HLA-DRA Differentially Associate with Type 1 Diabetes and Celiac Disease and Implicate Involvement of Complement System Genes C4A and C4B
Özkan Aydemir, Jeffrey A. Bailey, Daniel Agardh, Åke Lernmark, Janelle Annette Noble, Agnes Andersson Svärd, Elizabeth P. Blankenhorn, Hemang M. Parikh, Anette‐Gabriele Ziegler, Jorma Toppari, Beena Akolkar, William Hagopian, Marian J. Rewers, John P. Mordes, TEDDY Study Group
The paper identifies tri-SNP haplotypes in HLA-DRA associated with type 1 diabetes and celiac disease, and links them to differences in complement system genes C4A and C4B.
eLife · Feb 2, 2026Peer-reviewedGenetic & Genomic Medicine