Conformational ensemble-based framework enables rapid development of Lassa virus vaccine candidates
Nitesh Mishra, Gabriel Avillion, Sean Callaghan, Charlotte N. DiBiase, Jonathan Hurtado, Nathaniel Steven Liendo, Sarah M. Burbach, Terrence Messmer, Bryan S. Briney
This paper uses AI to predict and stabilize the conformational states of Lassa virus GPC, identifying vaccine candidates with improved expression and antigenicity.
bioRxiv · Nov 21, 2024 · PreprintImmunology