Supervised non-negative matrix factorization on cell-free DNA fragmentomic features enhances early cancer detection
Trung Hieu Tran, Ngoc Tan Pham, Van Thien Chi Nguyen, Dac Ho Vo, Thị Huệ Hạnh Nguyễn, Thi Trang Tran, Tuan Trong Tran, Truong Dang Huy Vo, Thi Huyen Dao, Huu Tam Phuc Nguyen, Thi Van Phan, Thị Minh Thi Hà, Thị Thùy Dương Ngô, Nhat Huy Tran, Nhat Thang Tran, , Trong Hieu Nguyen
This paper uses supervised non-negative matrix factorization on cfDNA fragmentomic features to improve early cancer detection, achieving high AUC scores in both pan-cancer and HCC-specific classifications.
bioRxiv · Dec 20, 2024 · PreprintBioinformatics