Predicting single mutation effects on binding affinity at protein-protein interfaces based on MMPBSA calculations
Jakob Noske, Thibaud Lepoivre, Maxim Janzen, Birte Höcker
The paper presents a physics-based method to predict single mutation effects on protein-protein binding affinity using MMPBSA calculations and evaluates its performance on SARS-CoV-2 and Armadillo-repeat systems.
bioRxiv · Sep 24, 2026 · PreprintBioinformatics