Jakob Noske

The paper presents a physics-based method to predict single mutation effects on protein-protein binding affinity using MMPBSA calculations and evaluates its performance on SARS-CoV-2 and Armadillo-repeat systems.

The paper evaluates three physics-based computational methods for predicting single residue effects on peptide binding specificity using experimental data on armadillo repeat proteins.

Protlego automates the design and structural analysis of chimeric proteins using Python, integrating fragment recombination and molecular dynamics simulations.