LMNA-Related Dilated Cardiomyopathy: Single-Cell Transcriptomics during Patient-derived iPSC Differentiation Support Cell type and Lineage-specific Dysregulation of Gene Expression and Development for Cardiomyocytes and Epicardium-Derived Cells with Lamin A/C Haploinsufficiency
Michael V. Zaragoza, Thuy-Anh Bui, Halida P. Widyastuti, Mehrsa Mehrabi, Zixuan Cang, Yutong Sha, Anna Grosberg, Qing Hua Nie
This study uses single-cell RNA sequencing of patient-derived iPSCs to identify gene expression and pathway dysregulation in LMNA haploinsufficiency affecting cardiomyocytes and epicardium-derived cells.
Cells · Sep 3, 2024Peer-reviewedGenomics