Phased epigenetic fragility and stability accelerate the genetic evolution of B-cells
Mark Y. Xiang, Haripriya Vaidehi Narayanan, Vaibhava Kesarwani, Tiffany Wang, Alexander Hoffmann
The paper shows that phased epigenetic fragility and stability in B-cells accelerate affinity maturation by modulating high-affinity outlier generation and removal during vaccine response.
bioRxiv · Jun 24, 2025 · PreprintSystems Biology