Author

Mark Y. Xiang

University of California, Los Angeles

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Alexander HoffmanniD· 2 shared Haripriya Vaidehi NarayananiD· 2 shared Vaibhava Kesarwani· 2 shared Helen J. HuangiD· 1 shared Tiffany Wang· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

5 top collaborators · 9 mutual co-author links

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2 shared papersSystems Biology

Alexander HoffmannORCID

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2 papers

Recent·Most cited

Phased epigenetic fragility and stability accelerate the genetic evolution of B-cells

Mark Y. Xiang, Haripriya Vaidehi Narayanan, Vaibhava Kesarwani, Tiffany Wang, Alexander Hoffmann

The paper shows that phased epigenetic fragility and stability in B-cells accelerate affinity maturation by modulating high-affinity outlier generation and removal during vaccine response.

bioRxiv · Jun 24, 2025 · PreprintSystems Biology

Synergy and antagonism in the integration of BCR and CD40 signals that control B-cell proliferation

Helen J. Huang, Haripriya Vaidehi Narayanan, Mark Y. Xiang, Vaibhava Kesarwani, Alexander Hoffmann

The paper develops a mathematical model to study how BCR and CD40 signals integrate to control B-cell proliferation and selection, revealing synergistic and antagonistic interactions.

Molecular Systems Biology · Jun 5, 2025Peer-reviewedImmunology