Inverse directions of association of higher physical activity and higher insulin resistance with human skeletal muscle cell type abundance and fiber type-level gene expression
Dan L. Ciotlos, Sarah C. Hanks, Arushi Varshney, Michael R. Erdos, Nandini Manickam, Heather M. Stringham, Peter Orchard, Erin M. Hill‐Burns, Narisu Narisu, Lori L. Bonnycastle, M. D. Sweeney, Jouko Saramies, Markku Laakso, Jaakko Tuomilehto, Timo A Lakka, , Laura J. Scott
The paper examines how physical activity and insulin resistance relate to skeletal muscle cell type abundance and gene expression in humans, finding inverse associations with specific cell types and gene expression patterns.
bioRxiv · Oct 27, 2025 · PreprintGenomics