M. D. Sweeney

The paper introduces FICTURE2, a statistical model that infers transcriptional programs from individual RNA molecules in spatial transcriptomics data, revealing spatial organization and cellular identity without segmentation.

This study evaluates sequence-to-omics models to improve reproducibility in genetic fine-mapping across eQTL datasets, showing reduced replication failure rates and enhanced SNP prioritization.

The paper examines how physical activity and insulin resistance relate to skeletal muscle cell type abundance and gene expression in humans, finding inverse associations with specific cell types and gene expression patterns.