Erosion of regenerative regulation: age-associated shifts in the skeletal muscle fiber epigenome and transcriptome
Keagan G. Moo, Peter Orchard, Arushi Varshney, Ricardo D’Oliveira Albanus, Nandini Manickam, Leena Kinnunen, Timo Lakka, Jouko Saramies, Markku Laakso, Jaakko Tuomilehto, Karen L. Mohlke, Michael Boehnke, Laura J. Scott, Heikki Koistinen, Francis S. Collins, Stephen C.J. Parker
The paper identifies age-associated changes in the skeletal muscle epigenome and transcriptome, revealing shifts in chromatin accessibility and gene expression linked to metabolic and senescence pathways.
bioRxiv · Aug 27, 2026 · PreprintBioinformatics