Generative modeling reveals the connection between nuclear morphology and gene expression
Shuo Wen, Ramón Viñas, Johannes Bues, Camille L G Lambert, Nadia Grenningloh, Timothée Ferrari, Elisa Bugani, Joern Pezoldt, Jillian R Love, Yinan Wan, Wouter R. Karthaus, Bart Deplancke, Maria Brbić
COSMIC, a generative model, quantifies the relationship between nuclear morphology and gene expression using paired single-cell data, revealing morphology-associated genes in prostate cancer and spatial transcriptomics of zebrafish embryos.
bioRxiv · Sep 30, 2026 · PreprintBioinformatics