Johannes Bues

COSMIC, a generative model, quantifies the relationship between nuclear morphology and gene expression using paired single-cell data, revealing morphology-associated genes in prostate cancer and spatial transcriptomics of zebrafish embryos.

The paper introduces IRIS, a platform integrating high-resolution imaging and single-cell RNA sequencing to link morphology with transcriptomes, revealing new nuclear-ER architectures in CD8+ T cells.

The paper investigates how gustatory organs contribute to food texture preference in Drosophila larvae, showing their role in texture evaluation and ingestion decisions.

The paper investigates multimodal and multisensory coding in Drosophila larval taste neurons using calcium imaging and single-cell transcriptomics, revealing complex integration of taste and mechanical stimuli.

The paper develops a synthetic gene circuit system to identify in vivo-responsive biosensors in gut bacteria, demonstrating their utility in both healthy and inflamed gut environments.