Decoding CBM2 binding modes: how similar folds achieve distinct substrate preferences
Susanne Hansen Troøyen, Andrew Philip Rennison, Tina Dahlgren, Peter Fojan, Marie Sofie Møller, Gastón Courtade
This study investigates how CBM2 proteins achieve distinct substrate preferences through a balance of topological complementarity, hydrophobic dehydration, and hydrogen-bonding interactions.
bioRxiv · Oct 16, 2026 · PreprintBiophysics