Osteocyte Differentiation Requires Glycolysis, But Mature Osteocytes Display Metabolic Flexibility
Matthew Prideaux, Mathilde Palmier, Yukiko Kitase, Lynda Faye Bonewald, Tom O’Connell
This study shows glycolysis is essential for osteocyte differentiation but mature osteocytes switch to metabolic flexibility, including increased fatty acid oxidation in response to mechanical stress.
bioRxiv · May 9, 2025 · PreprintCell Biology