Systematic Evaluation of Cell Type Deconvolution Methods for Plasma Cell-free DNA
Tongyue Sun, Jinqi Yuan, Yacheng Zhu, Yang Shen, Junpeng Zhou, Xinzhou Ge, Susu Qu, Wei Li, Jingyi Jessica Li, Yumei Li
This study benchmarks five methylation-based methods for cell type deconvolution of plasma cell-free DNA using deep whole-genome bisulfite sequencing data from 35 human cell types.
bioRxiv · Mar 25, 2024 · PreprintBioinformatics