Embryo-scale Visual Cell Sorting reveals a conserved transcriptomic signature of nucleolar size linked to proteostasis
Hyeon-Jin Kim, Sriram Pendyala, Josephine Lin, Tony Cooke, Gang Li, William Stafford Noble, Xinxian Deng, Christine M. Distèche, Cole Trapnell, Douglas M. Fowler
The paper develops a high-throughput Visual Cell Sorting workflow to link nuclear compartment morphology to single-nucleus transcriptomes, identifying a conserved transcriptional signature of nucleolar size linked to proteostasis.
bioRxiv · May 26, 2026 · PreprintGenomics