Author

TOPMed Analysis Working Group

University of Michigan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 2 Approach:statistical model· 2 Research Focus:database / resource· 1 Research Focus:dimensionality reduction· 1 Assay:DNA methylation· 1 Organism:human· 1 Approach:matrix factorization· 1 Assay:proteomics· 1

Frequent Co-Authors

Alex P. ReineriD· 2 shared Xiuqing GuoiD· 2 shared Alan M. KwongiD· 1 shared Albert V. SmithiD· 1 shared Angel C. Y. MakiD· 1 shared Ani W ManichaikuliD· 1 shared Brian E. CadeiD· 1 shared Celeste S. EngiD· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersGenomics

Alex P. ReinerORCID

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Author profile →

2 papers

Recent·Most cited

Uncovering Cross-Cohort Molecular Features with Multi-Omics Integration Analysis

Min-Zhi Jiang, François Aguet, Kristin Ardlie, Jiawen Carmen Chen, Elaine S. Cornell, Dan Cruz, Peter Durda, Stacey Gabriel, Robert Edgardo Gerszten, Xiuqing Guo, Craig W Johnson, Silva Kasela, Leslie A. Lange, Tuuli Lappalainen, Yongmei Liu, , TOPMed Analysis Working Group

This paper improves multi-omics integration by enhancing orthogonality in canonical vectors and demonstrates transferability across cohorts for proteomics and methylomics data.

bioRxiv · Nov 10, 2022 · PreprintGenomics

Robust, flexible, and scalable tests for Hardy-Weinberg Equilibrium across diverse ancestries

Alan M. Kwong, Thomas W. Blackwell, Jonathon LeFaive, Mariza de Andrade, John Barnard, Kathleen C. Barnes, John Blangero, Eric Boerwinkle, Esteban G. Burchard, Brian E. Cade, Daniel I. Chasman, Han Chen, Matthew P. Conomos, L. Adrienne Cupples, Patrick T. Ellinor, , Hyun Min Kang

This paper introduces RUTH, a new HWE test that accounts for population structure and genotype uncertainty, showing it reduces false positives compared to traditional methods.

Genetics · Mar 15, 2021Peer-reviewedGenetics