Promoter-targeted duplex RNAs activate TCF4 expression
Bethany A. Janowski, Tse Victor, Jiaxin Hu, Sarah A. Cobb, Khayden Dang, David R. Corey
The paper identifies promoter-targeted duplex RNAs that increase TCF4 expression in Pitt-Hopkins syndrome, supporting their use as a mutation-independent therapeutic strategy.
bioRxiv · Oct 4, 2026 · PreprintMolecular Biology