Jiaxin Hu

The paper identifies promoter-targeted duplex RNAs that increase TCF4 expression in Pitt-Hopkins syndrome, supporting their use as a mutation-independent therapeutic strategy.

This study identifies nuclear miRNA:Argonaute complexes and their chromatin-associated RNA targets, showing miRNA-mediated gene silencing occurs in both nucleus and cytoplasm.

The paper tests the effect of CPSF3 inhibitors YT-II-100 and JTE-607 on R-loop formation, finding global increases but no effect on specific R-loop positive control genes.

The paper introduces snQTL, a network-based method to map QTLs affecting gene co-expression networks, demonstrating its effectiveness in stickleback data by uncovering missed candidate genes.

This study shows lipid-modified siRNAs can inhibit TTR gene expression in the eye via intravitreal injection, suggesting a potential therapy for ocular TTR amyloidosis.

This study investigates how forced mouth opening induces hyperalgesia and peripheral sensitization in mice following temporomandibular joint injury.

The paper uses RNAseq to compare presymptomatic and late-stage FECD tissue, finding early splicing and gene expression changes that predict fibrosis and immune activation in late-stage disease.