Optogenetic construction of de novo integrin-adhesion complexes reveals role for biocondensation in adhesion nucleation
Minggang Xiong, Tsun Lam Leong, Mengyu Chen, Jiabei Chen, Tsun Chiu Lee, Cheng‐han Yu, Artem K. Efremov, Heath E. Johnson
This paper uses optogenetics to test how talin's activity and phase states influence integrin-adhesion complex (IAC) nucleation and stabilization, finding that biocondensation enables adhesion formation even without extracellular matrix.
bioRxiv · Oct 8, 2025 · PreprintCell Biology